Key result
Young adults with beta thalassaemia exhibited abnormal left ventricular remodelling, increased volumes and mass, and reduced systolic function, with ejection fraction <50% in 33 of 197 patients.
Why the study?
Does beta thalassaemia major affect left ventricular morphology and function in young adults without clinical signs of cardiopulmonary involvement?
Population
197 young adults with beta thalassaemia major, following an adequate transfusional and chelation treatment…
Design
Cross-sectional
Authors
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Subclinical LV impairment in asymptomatic young adults with beta thalassaemia supports surveillance imaging; leaves optimal ferritin targets for prevention open.
Observational (n=410)
No
Does beta thalassaemia major affect left ventricular morphology and function in young adults without clinical signs of cardiopulmonary involvement?
Young adults with beta thalassaemia major exhibit abnormal left ventricular remodelling and reduced systolic function, which is better preserved when serum ferritin is maintained below 1000 ng/ml.
G. Bosi (2003) conducted an observational in beta thalassaemia (n=410). Beta thalassaemia vs. Healthy subjects was evaluated on Left ventricular morphology and function. Young adults with beta thalassaemia exhibited abnormal left ventricular remodelling, increased volumes and mass, and reduced systolic function, with ejection fraction <50% in 33 of 197 patients.
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