Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1993Circulation

Left ventricular diastolic Doppler characteristics in beta-thalassemia major.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

What are the left ventricular diastolic Doppler characteristics in patients with beta-thalassemia major compared to normal individuals?

Population

88 beta-thalassemia major patients with normal left ventricular systolic function

Design

Cross-sectional

Authors

DKDimitrios Th. KremastinosDTDimitrios TsiaprasGTGeorgios A. Tsetsos

Discussion

Loading...

Member takes

Overview

Diastolic Doppler changes in beta-thalassemia may reflect preload or iron overload; leaves open prospective validation for risk stratification.

Structured PICO

What are the left ventricular diastolic Doppler characteristics in patients with beta-thalassemia major compared to normal individuals?

P
Population
88 beta-thalassemia major patients with normal left ventricular systolic function (34 young, age 15.1 +/- 3.2 years; 54 adults, age 25.1 +/- 3.6 years)
C
Comparator
46 normal individuals (22 young, age 13.8 +/- 2.4 years; 24 adult, age 25.3 +/- 4.1 years)
O
Outcome
Left ventricular inflow and pulmonary vein flow patterns (peak flow velocities E and A, E/A ratio, deceleration time, isovolumic relaxation time, pulmonary vein S and D velocities)surrogate

Doppler diastolic indexes in beta-thalassemia major patients with normal LV systolic function resemble conditions with increased preload, while severe iron loading leads to restrictive LV filling abnormalities.

Cite This Study

Kremastinos et al. (1993) studied this question.

synapsesocial.com/papers/6a7eb604358787acda4f7c6ehttps://doi.org/10.1161/01.cir.88.3.1127
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Filling and Emptying Patterns in Anemia due to Beta Thalassemia2008 · 8 citations
  2. 2Detection of Early Cardiac Dysfunction in Patients with Severe Beta-Thalassemia and Chronic Iron Overload1979 · 126 citations
  3. 3Global and Segmental Left Ventricular Function in β-Thalassemia2008 · 32 citations
  4. 4Left ventricular filling pattern in  -thalassaemia major -- a Doppler echocardiographic study1993 · 40 citations