March 1, 2002European Journal of EchocardiographyOpen Access

Doppler Characterization of Left Ventricular Diastolic Function in β-Thalassaemia Major. Evidence for an Early Stage of Impaired Relaxation

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Population

117 subjects, all with normal systolic function.

Design

Cross-sectional

Authors

WGWalid GharzuddineAmerican University of Beirut Medical Center

Discussion

Member takes

Implication

Supports early diastolic assessment in thalassaemia major; leaves open whether changes predict outcomes or respond to chelation.

Structured PICO

Population

117 subjects (50 with thalassaemia major, 38 with thalassaemia intermedia, and 29 normal controls), all with normal systolic function.

Outcome

Doppler echocardiographic parameters of left ventricular diastolic function (including E/A ratio, isovolumic relaxation time, and E wave)surrogate

In patients with thalassaemia major and normal systolic function, a prolonged isovolumic relaxation time is an early echocardiographic sign of diastolic dysfunction, likely due to iron overload.

Cite This Study

Walid Gharzuddine (2002) studied this question.

synapsesocial.com/papers/6a7f18956cd7289baa699ef6 https://doi.org/10.1053/euje.2001.0114

View Full Paper

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March 1, 2002European Journal of EchocardiographyOpen Access

Doppler Characterization of Left Ventricular Diastolic Function in β-Thalassaemia Major. Evidence for an Early Stage of Impaired Relaxation

View Full Paper

Ask AI

Bookmark

Population

117 subjects, all with normal systolic function.

Design

Cross-sectional

Authors

WGWalid GharzuddineAmerican University of Beirut Medical Center

Discussion

Member takes

Implication

Supports early diastolic assessment in thalassaemia major; leaves open whether changes predict outcomes or respond to chelation.

Structured PICO

Population

117 subjects (50 with thalassaemia major, 38 with thalassaemia intermedia, and 29 normal controls), all with normal systolic function.

Outcome

Doppler echocardiographic parameters of left ventricular diastolic function (including E/A ratio, isovolumic relaxation time, and E wave)surrogate

In patients with thalassaemia major and normal systolic function, a prolonged isovolumic relaxation time is an early echocardiographic sign of diastolic dysfunction, likely due to iron overload.

Cite This Study

Walid Gharzuddine (2002) studied this question.

synapsesocial.com/papers/6a7f18956cd7289baa699ef6 https://doi.org/10.1053/euje.2001.0114

Also Consider

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