Key result
Beta-thalassemia major was associated with a significantly higher E/A ratio (2.27 vs 1.50, p=0.01) and serum ferritin compared to controls, affecting left atrial size and ANP secretion.
Population
35 patients with beta-thalassemia with normal left ventricular systolic function and dimensions, and 11 age…
Design
Case-control
Authors
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May signal early diastolic dysfunction in beta-thalassemia major; hypothesis-generating for ferritin effects, needs prospective validation.
Cross-Sectional (n=46)
Absolute Event Rate: 2.27% vs 1.5%
p-value: p=0.01
In patients with beta-thalassemia and normal systolic function, increased serum ferritin levels are associated with increased left atrial size, altered E/A ratio, and consecutively increased ANP secretion, suggesting early diastolic dysfunction.
Brili et al. (1997) conducted a cross-sectional in beta-thalassemia (n=46). Beta-thalassemia major vs. Beta-thalassemia intermedia and healthy controls was evaluated on E/A ratio (p=0.01). Beta-thalassemia major was associated with a significantly higher E/A ratio (2.27 vs 1.50, p=0.01) and serum ferritin compared to controls, affecting left atrial size and ANP secretion.