Key result
In patients with stable angina, the age-adjusted Framingham risk score and flow-mediated dilation were independent predictors of cardiovascular events, but FMD provided no additive predictive value over AFRS alone.
Why the study?
Do risk assessments including Framingham risk score, flow-mediated dilation, pulse wave velocity, and biomarkers predict cardiovascular events in patients with stable angina?
Cohort (n=203)
No
Do risk assessments including Framingham risk score, flow-mediated dilation, pulse wave velocity, and biomarkers predict cardiovascular events in patients with stable angina?
In patients with stable angina, both the age-adjusted Framingham risk score and flow-mediated dilation independently predict cardiovascular events, but flow-mediated dilation does not provide additive predictive value over the Framingham risk score alone.
Answers are grounded in this paper and cite their sources.
AFRS suffices for risk prediction in stable angina; leaves open FMD's incremental utility in prospective cohorts.
Although the age-adjusted Framingham risk score (AFRS), flow-mediated dilation (FMD), brachial-ankle pulse wave velocity (baPWV), high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and free fatty acid (FFA) can predict future cardiovascular events (CVEs), a comparison of these risk assessments for patients with stable angina has not been reported. We enrolled 203 patients with stable angina who had been scheduled for coronary angiography (CAG). After CAG, 134 patients showed significant coronary artery disease. During 4.2 yr follow-up, 36 patients (18%) showed CVEs, including myocardial infarction, de-novo coronary artery revascularization, in-stent restenosis, stroke, and cardiovascular death. ROC analysis showed that AFRS, FMD, baPWV, and hsCRP could predict CVEs (with AUC values of 0.752, 0.707, 0.659, and 0.702, respectively, all P<0.001 except baPWV P=0.003). A Cox proportional hazard analysis showed that AFRS and FMD were independent predictors of CVEs (HR, 2.945; 95% CI, 1.572-5.522; P=0.001 and HR, 0.914; 95% CI, 0.826-0.989; P=0.008, respectively). However, there was no difference in predictive power between combining AFRS plus FMD and AFRS alone (AUC 0.752 vs. 0.763; z=1.358, P=0.175). In patients with stable angina, AFRS and FMD are independent predictors of CVEs. However, there is no additive value of FMD on the AFRS in predicting CVEs.
No takes yet. Share an insight, caveat, or question.
Park et al. (2014) conducted a cohort in Stable Angina (n=203). Age-adjusted Framingham risk score (AFRS) was evaluated on Composite of cardiovascular events (myocardial infarction, de-novo coronary revascularization, in-stent restenosis, stroke, and cardiovascular death) (HR 2.945, 95% CI 1.572-5.522, p=0.001). In patients with stable angina, the age-adjusted Framingham risk score and flow-mediated dilation were independent predictors of cardiovascular events, but FMD provided no additive predictive value over AFRS alone.
Synapse has enriched 10 related papers. Consider them for comparative context: