Key result
Review outlines calibration approaches across ion channel and cellular action potential scales in electrophysiology.
Why the study?
As cardiac electrophysiology models are increasingly used for quantitative rather than qualitative predictions, calibrating parameters to experimental data sets has become a crucial challenge.
Highlights fundamental concepts in cardiac model calibration and the need for reproducible descriptions of the calibration process.
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Stresses rigorous validation to curb overfitting in cardiac models; leaves open standardized benchmarks for reproducible calibration.
Whittaker et al. (2020) conducted a review in Cardiac electrophysiology models. Cardiac model calibration was evaluated. This review discusses the classic and latest approaches to calibration in the electrophysiology field at both the ion channel and cellular action potential scales.