What does this research mean for the field?

Cardiac resynchronization therapy partially reverses dyssynchronous heart failure-induced ion channel remodeling and abnormal calcium homeostasis, attenuating regional action potential heterogeneity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 24, 2009CirculationOpen Access

Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

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Why the study?

Does cardiac resynchronization therapy restore electrophysiological remodeling and abnormal calcium homeostasis in a canine model of dyssynchronous heart failure?

Structured PICO

Does cardiac resynchronization therapy restore electrophysiological remodeling and abnormal calcium homeostasis in a canine model of dyssynchronous heart failure?

Population

Adult dogs with left bundle-branch ablation and right atrial pacing (190 to 200 bpm) to induce dyssynchronous heart failure (DHF)

Intervention

3 weeks of resynchronization by biventricular pacing (CRT) following 3 weeks of right atrial pacing

Comparator

6 weeks of right atrial pacing (DHF) and nonfailing (control) dogs

Outcome

Electrophysiological properties including ion currents (IK1, IK, Ito, ICa), calcium transients, action potential duration, and early afterdepolarizations in isolated left ventricular anterior and lateral myocytessurrogate

In a canine model of dyssynchronous heart failure, CRT partially reverses electrophysiological and calcium handling remodeling, which may explain its antiarrhythmic and mechanical benefits.

Discussion

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Implication

Hypothesis-generating for CRT antiarrhythmic effects in dyssynchronous HF; leaves open translation to patients.

Cite This Study

Aiba et al. (2009) studied this question.

synapsesocial.com/papers/6a1ec275edce398519af2da0 https://doi.org/10.1161/circulationaha.108.794834

Topics

Heart failure HFrEF treatment Echocardiography

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Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider