Key result
Pediatric survivors of acute lymphoblastic leukemia demonstrated a lower reactive hyperemia index and elevated hsCRP compared to healthy controls, suggesting premature endothelial dysfunction.
Why the study?
ALL and its treatment are linked to endothelial dysfunction and late cardiovascular risk, but data on endothelial dysfunction in children after successful ALL treatment were lacking.
Does a history of acute lymphoblastic leukemia treatment increase surrogate markers of endothelial dysfunction in pediatric survivors?
Observational (n=40)
No
Does a history of acute lymphoblastic leukemia treatment increase surrogate markers of endothelial dysfunction in pediatric survivors?
Pediatric survivors of acute lymphoblastic leukemia exhibit signs of premature endothelial dysfunction, as evidenced by decreased reactive hyperemia index and elevated inflammatory biomarkers.
Answers are grounded in this paper and cite their sources.
May support vascular monitoring in pediatric ALL survivors; leaves open causality and need for prospective trials.
Acute lymphoblastic leukemia (ALL) and its treatment are associated with endothelial dysfunction (ED) and increased cardiovascular risk in adulthood. There are no data on ED in children after successful treatment of ALL. We aimed to assess new ED in these children using the plethysmographic reactive hyperemia index (RHI) and biomarkers that are known to be related to ED. In all, 22 children (mean 15.6 years), after successful treatment of ALL, and 18 healthy subjects were included in this prospective study. RHI, plasma concentrations of asymmetric dimethyl arginine (ADMA), high-sensitive CRP (hsCRP) and E-selectin were measured in all children. RHI values were significantly lower in ALL patients when compared with healthy controls (p<0.05). hsCRP was significantly increased in ALL patients compared with the control group (p<0.001). E-selectin plasma levels were higher in ALL patients as compared to healthy controls (p=0.05). This is the first study that combines both plethysmographic and biochemical methods to assess ED in ALL survivors. Significantly decreased RHI with elevated plasma concentrations of biochemical markers imply a possible association with premature ED in ALL patients. The combined diagnostic approach seems to be a valuable tool for more accurate detection of ED and preventive cardiovascular management in these patients.
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MASOPUSTOVÁ et al. (2018) conducted an observational in Acute Lymphoblastic Leukemia (ALL) Survivors (n=40). History of acute lymphoblastic leukemia and its treatment vs. Healthy subjects was evaluated on Reactive hyperemia index (RHI) (p=<0.05). Pediatric survivors of acute lymphoblastic leukemia demonstrated a lower reactive hyperemia index and elevated hsCRP compared to healthy controls, suggesting premature endothelial dysfunction.
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