Key result
Childhood ALL survivorship linked to ~13% lower reactive hyperemia index vs. healthy siblings.
Why the study?
Childhood acute lymphoid leukemia survivors are at increased risk of cardiovascular complications, and early identification of impaired vascular health may allow for interventions to improve outcomes.
Does childhood acute lymphoid leukemia survivorship impair vascular health compared to healthy siblings?
Observational (n=32)
Does childhood acute lymphoid leukemia survivorship impair vascular health compared to healthy siblings?
Absolute Event Rate: 1.54% vs 1.77%
p-value: p=0.0474
Childhood ALL survivors exhibit impaired vascular health compared to healthy siblings despite similar traditional cardiovascular risk factors, highlighting the potential need for early vascular monitoring.
ALL survivors may warrant vascular monitoring consideration; Level 4 evidence leaves open prospective validation.
BACKGROUND: Childhood cancer survivors are a growing population at risk for poor cardiac outcomes. Acute lymphoid leukemia (ALL) survivors are among those at increased risk of cardiovascular complications. Early identification of impaired vascular health may allow for interventions to improve these outcomes. The purpose of this study was to evaluate vascular health using peripheral artery tonometry in ALL survivors and compare results with healthy siblings. PROCEDURE: Sixteen ALL survivor, healthy sibling pairs, aged 8 to 20 years, were evaluated for vascular health and cardiovascular risk factors (body mass index, central adiposity, blood pressure, and fitness). One-tailed paired t test was used to compare the groups. RESULTS: Survivors were similar to siblings in cardiovascular risk measures but had poorer vascular health as measured by reactive hyperemia index (survivor RHI 1.54 vs. sibling 1.77; P=0.0474). CONCLUSION: This study reveals that even among survivors who are comparable to their healthy siblings in other traditional cardiovascular risks, there is evidence of poorer vascular health.
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Ruble et al. (2014) conducted an observational in Childhood Acute Lymphoid Leukemia (n=32). Childhood acute lymphoid leukemia survivorship vs. Healthy siblings was evaluated on Reactive hyperemia index (RHI) (p=0.0474). Childhood acute lymphoid leukemia survivors demonstrated poorer vascular health compared to healthy siblings, evidenced by a lower reactive hyperemia index (1.54 vs. 1.77; P=0.0474).
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