Key result
Cranial irradiation in childhood ALL survivors was associated with significantly higher BMI (30.4 vs 25.4, P=0.039) and triglyceride levels compared to chemotherapy alone.
Why the study?
Does prior cranial irradiation increase cardiovascular risk factors compared to chemotherapy alone in young adult survivors of childhood ALL?
Population
26 young adult survivors of childhood acute lymphoblastic leukemia, median age 20.9 years, median interval…
Comparison
Prior treatment with cranial irradiation (CRT) vs Prior treatment with chemotherapy only
Design
Cross-sectional
Follow-up
median 13.3 years since completion of therapy
Authors
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May support cardiometabolic monitoring in irradiated ALL survivors; leaves open causality and applicability to contemporary regimens.
Cross-Sectional (n=26)
Does prior cranial irradiation increase cardiovascular risk factors compared to chemotherapy alone in young adult survivors of childhood ALL?
Absolute Event Rate: 30.4% vs 25.4%
p-value: p=0.039
Young adult survivors of childhood ALL, especially those treated with cranial irradiation, exhibit a high prevalence of cardiovascular risk factors such as obesity and dyslipidemia.
Oeffinger et al. (2001) conducted a cross-sectional in Childhood acute lymphoblastic leukemia (ALL) survivors (n=26). Cranial irradiation (CRT) vs. Chemotherapy only was evaluated on Body mass index (BMI), blood pressure, fasting lipoprotein, glucose, and insulin levels (p=0.039). Cranial irradiation in childhood ALL survivors was associated with significantly higher BMI (30.4 vs 25.4, P=0.039) and triglyceride levels compared to chemotherapy alone.
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