What is the clinical evidence from this study?

Study design: Observational. Population: Acute lymphoblastic leukemia (ALL) in childhood (n=80). Intervention: Chemotherapy and cranial irradiation vs. Chemotherapy only. Primary outcome: Full dysmetabolic syndrome (DS) (p=0.017).

What does this research mean for the field?

Childhood ALL survivors treated with chemotherapy and cranial irradiation have a significantly higher prevalence of full dysmetabolic syndrome compared to those treated with chemotherapy alone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 30, 2007Journal of Pediatric Hematology/Oncology

Early Indicators of Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for Preventing Disease

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Key result

Cranial irradiation plus chemotherapy linked to ~175% higher dysmetabolic syndrome prevalence in childhood ALL survivors.

P=0.017
n=80

Why the study?

Early indicators of dysmetabolic syndrome in young survivors of childhood acute lymphoblastic leukemia were investigated to identify risk factors for metabolic complications.

Does cranial irradiation in addition to chemotherapy increase the risk of dysmetabolic syndrome in young survivors of childhood ALL?

Population

80 young survivors of childhood ALL (50 males, median age 13.9 y)

Comparison

Chemotherapy and cranial irradiation (18 Gy) vs chemotherapy only

Design

Observational cross-sectional study

Follow-up

Median interval 6.3 years since completion of chemotherapy

Authors

GTGeorgios G TrimisAthens Medical Center MMMaria MoschoviNational and Kapodistrian University of Athens IPIoannis PapassotiriouNational and Kapodistrian University of Athens

Discussion

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Implication

Supports enhanced metabolic surveillance in irradiated ALL survivors; leaves open causality and requires prospective confirmation.

Study Design

Type

Observational (n=80)

Structured PICO

Does cranial irradiation in addition to chemotherapy increase the risk of dysmetabolic syndrome in young survivors of childhood ALL?

Population

80 young survivors of childhood acute lymphoblastic leukemia (median age 13.9 years, 37.5% female) evaluated at a median of 6.3 years after completion of chemotherapy.

Exposure

Chemotherapy and cranial irradiation (18 Gy) (group B, n=18)

Comparator

Chemotherapy only (group A, n=62)

Outcome

Prevalence of early indicators of dysmetabolic syndrome (obesity, increased blood pressure, increased serum triglycerides, reduced HDL cholesterol, increased fasting insulin, osteopenia, reduced IGF-1, thyroid hormone abnormalities, and full dysmetabolic syndrome)surrogate

Main Result

Absolute Event Rate: 22% vs 8%

p-value: p=0.017

Young survivors of childhood ALL, particularly those treated with cranial irradiation, have a significantly increased risk of developing dysmetabolic syndrome early after therapy completion.

Cite This Study

Trimis et al. (2007) conducted an observational in Acute lymphoblastic leukemia (ALL) in childhood (n=80). Chemotherapy and cranial irradiation vs. Chemotherapy only was evaluated on Full dysmetabolic syndrome (DS) (p=0.017). Childhood ALL survivors treated with chemotherapy and cranial irradiation had a significantly higher prevalence of full dysmetabolic syndrome compared to chemotherapy alone (22% vs 8%; P=0.017).

synapsesocial.com/papers/6aaa66b384ffb20652eb8f28 https://doi.org/10.1097/mph.0b013e318059c249

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Early Indicators of Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for Preventing Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Early Indicators of Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for Preventing Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider