Obesity and hypertension among children after treatment for acute lymphoblastic leukemia
Why the study?
Does contemporary therapy for childhood ALL, specifically corticosteroid exposure, increase the risk of obesity and hypertension in survivors?
Population
165 childhood acute lymphoblastic leukemia survivors, ages 2-20 at diagnosis, enrolled on pediatric…
Comparison
Contemporary ALL therapy vs Lowest level of corticosteroid exposure
Design
Cohort
Follow-up
2-3 years after completion of therapy
Authors
Discussion
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Implication
May warrant cardiometabolic monitoring in high-exposure ALL survivors; extends observational data but leaves causal confirmation open.
Structured PICO
Does contemporary therapy for childhood ALL, specifically corticosteroid exposure, increase the risk of obesity and hypertension in survivors?
P
Population
165 childhood acute lymphoblastic leukemia (ALL) survivors, ages 2-20 at diagnosis (median age 4.8 years), enrolled on pediatric cooperative group trials from 1993-2003.
I
Intervention
Contemporary ALL therapy (including varying levels of corticosteroid exposure and cranial radiotherapy)
C
Comparator
Lowest level of corticosteroid exposure (for risk factor analysis)
O
Outcome
Prevalence of obesity (BMI ≥30 or ≥95% for age) and hypertension (BP ≥140/90 mm Hg or 95% for age and height plus 5 mm Hg) and treatment-related risk factorssurrogate
Childhood ALL survivors treated with contemporary therapy, particularly those exposed to high doses of corticosteroids, remain at increased risk for obesity and hypertension years after treatment completion.
Cite This Study
Chow et al. (2007) studied this question.