What question did this study set out to answer?

To examine the incidence, pattern, and sex differences of obesity in pediatric survivors of acute lymphoblastic leukaemia following cranial radiotherapy.

August 1, 1994Archives of Disease in ChildhoodOpen Access

Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia.

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Why the study?

Does cranial radiotherapy combined with chemotherapy increase the risk of obesity in children treated for acute lymphoblastic leukaemia compared to chemotherapy alone?

Population

40 children treated for acute lymphoblastic leukaemia according to Medical Research Council protocols UKALL…

Comparison

Chemotherapy plus cranial radiotherapy at a dose… vs 18 age-matched children who received…

Design

Cohort

Follow-up

4 years

Authors

IOIsaac OdameHospital for Sick Children JRJohn ReillyBrigham and Women's Hospital BGB GibsonSt Bartholomew's Hospital

Discussion

Member takes

Implication

Cranial radiotherapy may heighten long-term obesity risk in girls with ALL; leaves open causality and relevance to current regimens.

Key Points

To examine the incidence, pattern, and sex differences of obesity in pediatric survivors of acute lymphoblastic leukaemia following cranial radiotherapy.
Conducted a retrospective analysis of 40 children (19 boys, 21 girls) treated for acute lymphoblastic leukaemia under UKALL VIII and X protocols, which included 1800 cGy cranial radiotherapy.
Calculated BMI Z-scores from standardized tables at diagnosis, two years, and four years post-diagnosis, comparing changes using paired t-tests.
Evaluated outcomes against a control group of 18 age-matched children treated with chemotherapy without cranial radiotherapy.
Mean BMI Z-scores at diagnosis did not differ significantly between ALL boys, ALL girls, and chemotherapy-only controls.
At two years post-diagnosis, the ALL cohort demonstrated a significant increase in BMI, with the elevation being particularly prominent among girls.
At four years, BMI declined slightly in ALL boys but escalated further in ALL girls (57% reached BMI Z-scores > 2), whereas the control group showed non-significant BMI increases at both two and four years.

Structured PICO

Does cranial radiotherapy combined with chemotherapy increase the risk of obesity in children treated for acute lymphoblastic leukaemia compared to chemotherapy alone?

Population

40 children (19 boys and 21 girls) treated for acute lymphoblastic leukaemia (ALL) according to Medical Research Council protocols UKALL VIII and X

Intervention

Chemotherapy plus cranial radiotherapy at a dose of 1800 cGy

Comparator

18 age-matched children who received chemotherapy but no radiotherapy

Outcome

Change in Body Mass Index (BMI) Z scores at two and four years from diagnosissurrogate

Cranial irradiation is an important factor in the development of obesity, particularly in girls, following treatment for acute lymphoblastic leukaemia.

Cite This Study

Odame et al. (1994) studied this question.

synapsesocial.com/papers/6a7e02cc286d888403cdb589 https://doi.org/10.1136/adc.71.2.147

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Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider