What question did this study set out to answer?

To evaluate the safety and feasibility of cotransplantation of culture-expanded MSCs and HSCs in patients with hematologic malignancies.

April 21, 2005Biology of Blood and Marrow TransplantationOpen Access

Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

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Authors

HLHillard M. LazarusNorthwestern University OKOmer N. KoçAnkara University SDSteven M. DevineAllegheny Health Network

Discussion

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Implication

Randomized trial demonstrates the feasibility and safety of MSC and HSC cotransplantation in hematologic malignancy patients, suggesting a new treatment avenue.

Key Points

To evaluate the safety and feasibility of cotransplantation of culture-expanded MSCs and HSCs in patients with hematologic malignancies.
Open-label, multicenter trial with 46 patients receiving MSC and HSC cotransplantation.
Patients received conditioning regimens and GVHD prophylaxis with methotrexate and cyclosporine.
MSCs were administered intravenously four hours prior to HSC infusion.
Median time to neutrophil engraftment was 14.0 days, and median time to platelet engraftment was 20 days.
Grade II to IV acute GVHD occurred in 28% of patients, with chronic GVHD observed in 61% of survivors.
53% of patients had disease- or progression-free survival at 2 years post MSC infusion.

Cite This Study

Lazarus et al. (2005) studied this question.

synapsesocial.com/papers/6a1ec8a5bf2a5d44faaf5147 https://doi.org/10.1016/j.bbmt.2005.02.001

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Implication

Randomized trial demonstrates the feasibility and safety of MSC and HSC cotransplantation in hematologic malignancy patients, suggesting a new treatment avenue.

Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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