Key result
Central norepinephrine depletion was investigated to determine its effect on the development of renovascular hypertension and the central renin-angiotensin system in rats.
Why the study?
Does central norepinephrine depletion affect the development of 2 kidney-2 clip renovascular hypertension in rats?
Does central norepinephrine depletion affect the development of 2 kidney-2 clip renovascular hypertension in rats?
This preclinical study was designed to evaluate the effect of central norepinephrine depletion on the development of renovascular hypertension and the central renin-angiotensin system in rats.
No clinical implications from this rat model; leaves open central norepinephrine's role in renovascular hypertension and RAS.
Some reports have stated that central norepinephrine (NE) depletion inhibited the development of hypertension in the rat. On the other hand, this pharmacological treatment induces changes on the central renin-angiotensin system. The present study was designed to follow the development of 2 kidney-2 clip (2k–2c) renovascular hypertension in rats depleted of central NE and to analyze the central.
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Basso et al. (1993) studied this question. Central norepinephrine depletion was investigated to determine its effect on the development of renovascular hypertension and the central renin-angiotensin system in rats.
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