A Detailed Cardiovascular Characterization of Obesity Without the Metabolic Syndrome
Why the study?
Does obesity without metabolic syndrome worsen markers of subclinical cardiovascular disease in 70-year-old adults compared to normal weight without metabolic syndrome?
Population
1016 subjects at age 70 from the Prospective Investigation of the Vasculature in Uppsala Seniors study
Comparison
Obesity (BMI ≥30 kg/m²) without metabolic syndrome vs Normal weight without metabolic syndrome
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Obesity without MetS may not be benign for subclinical CVD risk in older adults; hypothesis-generating, needing prospective validation.
Structured PICO
Does obesity without metabolic syndrome worsen markers of subclinical cardiovascular disease in 70-year-old adults compared to normal weight without metabolic syndrome?
P
Population
1016 subjects at age 70 from the Prospective Investigation of the Vasculature in Uppsala Seniors study
I
Intervention
Obesity (BMI ≥30 kg/m²) without metabolic syndrome
C
Comparator
Normal weight (BMI <25 kg/m²) without metabolic syndrome
O
Outcome
Markers of subclinical cardiovascular disease including endothelial reactivity, arterial compliance, carotid artery atherosclerosis, echocardiography, and coagulation/fibrinolysissurrogate
Obesity without metabolic syndrome is associated with multiple markers of subclinical cardiovascular disease, indicating it is not a benign condition.
Cite This Study
Lind et al. (2011) studied this question.