Key result
Metabolic syndrome, not obesity alone, is linked to higher cardiovascular risk, while ~62% progress to MetS.
Why the study?
This study aimed to investigate how obesity and metabolic syndrome modify the risk of cardiovascular diseases, atrial fibrillation, and mortality over very long-time follow-up.
Does the presence of obesity and/or metabolic syndrome increase the risk of cardiovascular disease, atrial fibrillation, and mortality in a long-term follow-up?
Population
1045 subjects grouped according to presence of obesity and MetS
Comparison
Four subgroups according to presence of obesity and MetS
Follow-up
24 years for CVD and AF, 30 years for total mortality
Authors
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Metabolic syndrome, not obesity alone, signals higher risk; leaves open whether preventing progression improves outcomes.
Cohort (n=1,045)
Does the presence of obesity and/or metabolic syndrome increase the risk of cardiovascular disease, atrial fibrillation, and mortality in a long-term follow-up?
Metabolic syndrome, rather than obesity alone, drives the long-term risk of mortality, cardiovascular disease, and atrial fibrillation, though metabolically healthy obesity often progresses to metabolic syndrome over time.
Käräjämäki et al. (2022) conducted a cohort in Obesity and metabolic syndrome (n=1,045). Obesity and metabolic syndrome vs. Absence of obesity and/or metabolic syndrome was evaluated on Cardiovascular disease events, atrial fibrillation, and total mortality. Metabolic syndrome, but not obesity alone, was associated with a greater risk of mortality and cardiovascular diseases, while 62% of metabolically healthy obese subjects progressed to MetS.
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