What does this research mean for the field?

Estrogen modulates angiotensinogen gene expression in a tissue-specific manner, significantly upregulating mRNA levels in the liver, kidney, and aorta, but not in cardiac atria. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1992Journal of Hypertension

Regulation of angiotensinogen gene expression by estrogen

View Full Paper

Ask AI

Bookmark

Population

Adult female Sprague-Dawley rats, ovariectomized (OVX) 21 days postsurgery

Comparison

17 beta-estradiol injection vs Ovariectomized control rats and intact female rats

Design

Preclinical

Follow-up

up to 24 hours (assessed at 0, 1, 4, and 24 h)

Authors

MGMichael S. GordonMonash Children’s Hospital WCWilliam W. ChinUniversity of Iowa MSMargaret A. ShupnikUniversity of Virginia

Discussion

Member takes

Implication

Suggests estrogen modulates angiotensinogen tissue-specifically in rats; leaves open relevance to human hypertension.

Structured PICO

Population

Adult female Sprague-Dawley rats, ovariectomized (OVX) 21 days postsurgery

Intervention

17 beta-estradiol (E2; 10 micrograms/100 mg body weight) injection

Comparator

Ovariectomized (OVX) control rats and intact female rats

Outcome

Angiotensinogen mRNA levels in multiple tissues (liver, aorta, kidney, cardiac atria, hypothalamus, whole brain, pituitary gland) measured by Northern blot analysissurrogate

Estrogen modulates angiotensinogen gene expression in a tissue-specific manner in ovariectomized rats.

Cite This Study

Gordon et al. (1992) studied this question.

synapsesocial.com/papers/6a1ed19c38eb9bccee7e7dbb https://doi.org/10.1097/00004872-199204000-00007

View Full Paper

Ask AI

Bookmark

Regulation of angiotensinogen gene expression by estrogen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of angiotensinogen gene expression by estrogen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider