Population
Ovariectomized female rats
Comparison
17beta-estradiol (E(2)) injection vs Vehicle injection
Design
Preclinical
Authors
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May link estrogen loss to higher postmenopausal aldosterone and CVD risk; leaves open human validation before any clinical relevance.
Estrogen reduces AT1 receptor density and Ang II-induced aldosterone release in the adrenal zona glomerulosa primarily by inhibiting AT1 receptor translation, providing a potential mechanism for increased cardiovascular disease risk after menopause.
Wu et al. (2003) studied this question.
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