Why the study?
Does estrogen administration upregulate renal angiotensin II AT2 receptors in mice?
Population
Male, female, ovariectomized, and estrogen-treated ovariectomized mice
Comparison
Estrogen administration and ovariectomy vs Male mice, intact female mice, and…
Design
Preclinical
Authors
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Supports estrogen-AT2 renal interactions in estrogen-deficient models; leaves open human translation and clinical relevance.
Does estrogen administration upregulate renal angiotensin II AT2 receptors in mice?
Estrogen upregulates renal angiotensin II AT2 receptors in mice, suggesting a potential mechanism for its protective cardiovascular and renal effects.
Armando et al. (2002) studied this question.