Key result
Outpatient PE treatment guided by validated triage yields low adverse event rates of ~0.6%.
Why the study?
While home treatment selected by a validated triage tool is considered safe in acute pulmonary embolism, its applicability in underrepresented subgroups remains uncertain.
Comparison
Home treatment across clinical subgroups
Design
Individual patient-level data meta-analysis
Follow-up
30 days
Authors
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Supports home treatment for selected acute PE patients; extends meta-analytic evidence for validated triage tools.
Meta-Analysis (n=2,694)
Yes
Home treatment for acute pulmonary embolism is safe when patients are selected using validated triage tools, with very low rates of adverse events and mortality.
Luijten et al. (2024) conducted a meta-analysis in Acute pulmonary embolism (n=2,694). Home treatment (discharge within 24 hours) was evaluated on 14-day incidence of adverse events (composite of recurrent venous thromboembolism, major bleeding, and/or all-cause mortality) (95% CI 0.28-0.84). Home treatment of acute pulmonary embolism in patients selected by validated triage tools was associated with a very low 14-day incidence of adverse events (0.56%) and all-cause mortality (0.11%).
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