Key result
Direct oral anticoagulants are considered essential for managing venous thromboembolism in the elderly due to their efficacy and safety, though specific data in fragile populations remain limited.
Why the study?
Venous thromboembolic events are common in the geriatric population, but direct oral anticoagulant management remains complex due to a lack of specific data in this polymedicated, fragile population.
DOACs are effective and safe for managing VTE in the elderly, but careful consideration of pharmacokinetics, drug interactions, and comorbidities is required.
INTRODUCTION: Management of venous thromboembolic events (VTE) has been completely changed after the introduction of direct oral anticoagulants (DOAC). VTE is common in the geriatric population, but the management of DOACs remains complex because of the lack of specific data in this polymedicated fragile population.An exhaustive search of anticoagulants in the indication of VTE was performed on PubMed, including data from clinical trials, observational studies, real-world data, drug-drug interaction studies, as well as various guidelines from scientific societies. AREAS COVERED: The present review aims to summarize our current knowledge on the era of DOACs in the management of VTE in the elderly. This involves learning the pharmacokinetics/pharmacodynamics of drugs specific to geriatrics, the problem of drug-drug interactions, and the main randomized clinical trials validating the use of DOACs. EXPERT OPINION: DOACs have become an essential part of the management of VTE in the elderly, both for their efficacy and safety. However, we are faced with a list of unmet needs, such as the relevance of DOACs in the very elderly, cancer patients, and those with renal impairment. Clinicians and pharmacists must remain cautious about comedications, as well as about the patient's comorbidities.
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Lafaie et al. (2022) conducted a review in Venous thromboembolic events (VTE). Direct oral anticoagulants (DOAC) was evaluated. Direct oral anticoagulants are considered essential for managing venous thromboembolism in the elderly due to their efficacy and safety, though specific data in fragile populations remain limited.
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