Key result
Following percutaneous coronary intervention, female patients were significantly more likely to be nondippers (27.1% vs 12.1%; p=0.05), and nondippers exhibited higher mean systolic blood pressure (p=0.001).
Why the study?
Does 24-hour ambulatory blood pressure monitoring reveal sex-related differences and prognostic BP variables in patients after percutaneous transluminal coronary angioplasty?
Observational (n=100)
No
Does 24-hour ambulatory blood pressure monitoring reveal sex-related differences and prognostic BP variables in patients after percutaneous transluminal coronary angioplasty?
Absolute Event Rate: 27.1% vs 12.1%
p-value: p=0.05
Immediate post-PCI female patients are more likely to be nocturnal BP nondippers, a group associated with higher systolic and pulse pressures.
Aim In recent studies, lack of fall in nocturnal blood pressure (BP) has been presented as an independent predictor of poor prognosis. The aim of this study is to investigate the prognostic value of various variables of BP by 24-hour ambulatory blood pressure (ABP) measurement and sex-related differences after percutaneous transluminal coronary angioplasty (PTCA). Methods This study included 100 patients who underwent PTCA in the authors’ institute from June 2017 to January 2018. They were monitored by 24-hour ABP for 1 day in the hospital. Results One hundred patients were recruited in this study with mean age of 61.64 years, with female-to-male ratio of 0.27:1. All demographic, clinical, and laboratory parameters including the ABP parameters were comparable between females and males, except smoking and alcoholism that were more frequent in males. Out of 100 patients, 41 had nocturnal dipping in BP and 59 did not have nocturnal dipping. In this study, the variables among nondippers, 16 (27.1%) were females, 43 (72.8%) were males, 45 (63.3%) had diabetes mellitus (DM), 46 (75.4%) had hypertension (HTN), mean systolic blood pressure (SBP) was 141.7 ± 13.9 mm Hg, mean diastolic blood pressure (DBP) was 86.34 ± 5.64 mm Hg, mean pulse pressure (PP) was 55.39 ± 9.25 mm Hg, and pulse-wave velocity (PWV) was 6.69 ± 2.22 m/s. In females were more nondippers (27.1%) than dippers (12.1%), which was statistically significant (p = 0.05). Nondippers were more among hypertensive patients (77.9% vs. 36.5%; p = 0.00). Higher mean SBP (p = 0.001), higher mean BP (p = 0.032), and higher mean pulse pressure (p = 0.00) were observed in nondippers. However, age, ejection fraction (EF), presence of DM, coronary artery disease (CAD) severity, type of presentation, and PWV were not different in dipper versus nondippers. Conclusion With comparable clinical, laboratory parameters along with BP parameters between females and males, immediate post-percutaneous coronary intervention (PCI) patients, female PCI patients had more nondippers (p = 0.05). Overall nondippers had higher SBP, mean BP, and PP than dippers. Diabetes, severity of CAD, and type of presentation of CAD (as ACS or CSA) did not influence the nocturnal dipping quality of the BP.
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Kenchi et al. (2018) conducted an observational in Post-percutaneous transluminal coronary angioplasty (PTCA) (n=100). Lack of nocturnal blood pressure dipping (nondippers) vs. Nocturnal blood pressure dipping (dippers) was evaluated on Female sex (p=0.05). Following percutaneous coronary intervention, female patients were significantly more likely to be nondippers (27.1% vs 12.1%; p=0.05), and nondippers exhibited higher mean systolic blood pressure (p=0.001).
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