Key result
Following PTCA, females were more frequently nondippers than males, and nondippers had higher pulse pressure (P<0.001), with an overall 1-year major adverse cardiac event rate of 1.7%.
Why the study?
Lack of fall in nocturnal BP is an independent predictor of poor prognosis, but the prognostic value of 24-h ABPM variables and associated gender differences after PTCA needed determination.
Do blood pressure variables on 24-h ABPM and gender differences predict 1-year outcomes following PTCA?
Observational (n=58)
Do blood pressure variables on 24-h ABPM and gender differences predict 1-year outcomes following PTCA?
Following PTCA, females were more likely to be nondippers than males, though 1-year clinical events were comparable and overall MACE was low (1.7%).
Hypothesis-generating link between female sex, nondipping, and pulse pressure post-PTCA; leaves open ABPM predictive value for MACE.
Background and Aim: Lack of fall in nocturnal blood pressure (BP) is an independent predictor of poor prognosis. This study determined the prognostic value of BP variables by 24-h ambulatory BP monitoring (ABPM) and associated gender differences after percutaneous transluminal coronary angioplasty (PTCA). Methods: A total of 58 patients underwent PTCA who were subjected to 24-h ABPM and followed for 1-year. Results: All demographic and clinical parameters (female: 10; mean age: 59.4 years), including ABP parameters, were comparable between genders, except smoking and alcoholism. Among nondippers (n = 33), 8 (24.2%) were females, 25 (75.8%) males, 30 (90.9%) diabetes mellitus (DM), 32 (97.0%) hypertension, and had mean diastolic BP (DBP): 86.15 ± 6.31 mmHg, pulse pressure (PP): 55.85 ± 10.09 mmHg, and pulse-wave velocity (PWV): 6.21 ± 01.87 m/s. Most females were nondippers (8 [24.2%]). Nondippers were older in age (P < 0.02) with higher PP (P < 0.001), DBP, and mean BP (MBP). Ejection fraction, presence of coronary artery disease (CAD) or DM, and PWV were comparable between both groups. At 1-year follow-up, one out of two symptomatic patients died, and the other developed chronic stable angina. The major adverse cardiac event rate was 1.7% (1/58). Each left ventricular dysfunction was deteriorated, and contrast-induced nephropathy was seen in three patients. Conclusion: Immediately after PTCA, females were more nondippers than males. Overall, nondippers had higher DBP, MBP, and PP. Nocturnal dipping was not influenced by the presence of DM or CAD. At 1-year follow-up, combined clinical and laboratory events were comparable.
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Jyotsna et al. (2019) conducted an observational in Post-percutaneous transluminal coronary angioplasty (n=58). Female gender vs. Male gender was evaluated on Major adverse cardiac events. Following PTCA, females were more frequently nondippers than males, and nondippers had higher pulse pressure (P<0.001), with an overall 1-year major adverse cardiac event rate of 1.7%.
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