Key result
Female sex was associated with lower absolute risks for death and cardiovascular events compared to men (HR 0.66 and 0.62; P<0.001), but a steeper relationship between 24-hour BP and CV events.
Why the study?
Do sex differences exist in the relative and absolute risks of cardiovascular events and mortality associated with ambulatory blood pressure?
Population
9357 subjects recruited from 11 populations, mean age 52.8 years, 47% women.
Comparison
Conventional and 24-hour ambulatory blood… vs Comparison between women and men
Design
Cohort
Follow-up
median 11.2 years
Authors
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Women had lower absolute CV risks yet steeper 24-hour BP-event slopes; hypothesis-generating for sex-specific ambulatory BP thresholds.
Cohort (n=9,357)
Yes
Do sex differences exist in the relative and absolute risks of cardiovascular events and mortality associated with ambulatory blood pressure?
Hazard Ratio: 0.66
p-value: p=<0.001
The steeper relationship between ambulatory blood pressure and cardiovascular events in women suggests a greater potential benefit for blood pressure-lowering treatment in women compared to men.
Boggia et al. (2011) conducted a cohort in Cardiovascular risk (n=9,357). Female sex vs. Male sex was evaluated on Death (HR 0.66, p=<0.001). Female sex was associated with lower absolute risks for death and cardiovascular events compared to men (HR 0.66 and 0.62; P<0.001), but a steeper relationship between 24-hour BP and CV events.
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