Key result
Higher 24-hour systolic blood pressure (per 20 mm Hg increment) was significantly associated with a greater risk of cardiovascular events (HR 1.45; 95% CI 1.37-1.54; P<.001).
Why the study?
Blood pressure is a known risk factor for overall mortality and cardiovascular outcomes, but it is uncertain which blood pressure index is most strongly associated with these outcomes.
Are 24-hour and nighttime blood pressure measurements more strongly associated with mortality and cardiovascular events compared to office-based measurements in adults?
Population
11 135 adults from Europe, Asia, and South America
Comparison
Observer or automated office BP vs 24-hour, daytime, nighttime BP, and dipping ratio
Design
Longitudinal population-based cohort study
Follow-up
Median of 13.8 years
Authors
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Ambulatory SBP monitoring may refine CV risk stratification; extends observational associations but leaves superiority over office BP open.
Cohort (n=11,135)
Yes
Are 24-hour and nighttime blood pressure measurements more strongly associated with mortality and cardiovascular events compared to office-based measurements in adults?
Hazard Ratio: 1.45 (95% CI 1.37–1.54)
p-value: p=<.001
Higher 24-hour and nighttime blood pressure measurements are significantly associated with greater risks of death and composite CV outcomes, suggesting they may be optimal for estimating CV risk.
Yang et al. (2019) conducted a cohort in Cardiovascular risk (n=11,135). 24-hour and nighttime blood pressure was evaluated on Composite CV event (CV mortality, nonfatal coronary events, heart failure, and stroke) (HR 1.45, 95% CI 1.37-1.54, p=<.001). Higher 24-hour systolic blood pressure (per 20 mm Hg increment) was significantly associated with a greater risk of cardiovascular events (HR 1.45; 95% CI 1.37-1.54; P<.001).
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