Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

Gaojie Fan; Qing Liu; Jianing Bi; Qing Fang; Fei Luo; Xiaofeng Huang; Heng Li; Wenwen Guo; Binghai Liu; Lianyan Yan; Youjie Wang; Lulu Song

doi:10.1093/humrep/deae250

November 8, 2024Human Reproduction

Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

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Key Points

This study investigates the relationship between reproductive factors and biological aging and assesses how biological aging influences premature mortality.
Prospective cohort study including 223,729 women aged 40-69 from the UK Biobank.
Reproductive factors were assessed via questionnaires, and biological aging was measured using PhenoAge-Accel.
Multiple linear regression and mediation analysis were conducted to explore associations and mediation effects.
Early menarche (<12 years) associated with a 0.37 increase in PhenoAge-Accel (95% CI: 0.30, 0.44).
PhenoAge-Accel mediated 6.0%-29.7% of the associations between reproductive factors and premature mortality.
Unfavorable lifestyle combined with reproductive risk factors resulted in the highest PhenoAge-Accel measurement.

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Implication

Prospective cohort study examines reproductive factors' impact on biological aging and mortality in women, suggesting healthier lifestyles mitigate risks.

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Cite This Study

Fan et al. (2024) studied this question.

synapsesocial.com/papers/6a1ed567eed4f0c78fa44c44 https://doi.org/10.1093/humrep/deae250

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Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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