Why the study?
Does volume overloading from an aortopulmonary shunt alter myocardial lactate and glucose metabolism in lambs at rest and during exercise?
Does volume overloading from an aortopulmonary shunt alter myocardial lactate and glucose metabolism in lambs at rest and during exercise?
Volume overloading from aortopulmonary shunts increases myocardial reliance on carbohydrate oxidation (lactate and glucose) both at rest and during exercise in a lamb model.
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Highlights metabolic shifts in volume-overload models; hypothesis-generating and requires human validation.
Beaufort‐Krol et al. (1998) studied this question.
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