Key result
Adaptive servoventilation significantly improved left ventricular ejection fraction by an absolute 4.04%, along with exercise capacity and respiratory stability, in patients with chronic heart failure and Cheyne-Stokes respiration.
Why the study?
Does adaptive servoventilation improve cardiac function and respiratory stability in patients with chronic heart failure and Cheyne-Stokes respiration?
Population
105 patients with chronic heart failure and Cheyne-Stokes respiration
Comparison
Adaptive servoventilation treatment vs Controls
Design
Cohort
Follow-up
6.7 ± 3.2 months
Authors
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Supports further investigation of adaptive servoventilation in HFrEF with Cheyne-Stokes respiration; hypothesis-generating pending randomized evidence.
Cohort (n=115)
Single-blind
No
Does adaptive servoventilation improve cardiac function and respiratory stability in patients with chronic heart failure and Cheyne-Stokes respiration?
Effect estimate: absolute increase of 4.04%
Absolute Event Rate: 34% vs 28.1%
p-value: p=0.003
In patients with HFrEF and Cheyne-Stokes respiration, adherence to adaptive servoventilation is associated with improvements in surrogate markers of cardiac function, exercise capacity, and respiratory stability.
Oldenburg et al. (2010) conducted a cohort in Chronic heart failure with Cheyne-Stokes respiration (n=115). Adaptive servoventilation vs. Control group (rejected or non-compliant to ASV) was evaluated on Left ventricular ejection fraction (absolute increase of 4.04%, p=0.003). Adaptive servoventilation significantly improved left ventricular ejection fraction by an absolute 4.04%, along with exercise capacity and respiratory stability, in patients with chronic heart failure and Cheyne-Stokes respiration.
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