Key result
Post-CABG LVEF improvement at six months is linked to ~74% lower all-cause mortality.
Why the study?
Whether short-term improvement in ejection fraction after CABG improves survival outcomes in patients with preoperative left ventricular dysfunction remains uncertain.
Does postoperative LVEF improvement predict better survival outcomes in patients with ischemic cardiomyopathy and preoperative LVEF < 50% undergoing CABG?
Population
362 patients with LVEF < 50% undergoing CABG
Comparison
Postoperative LVEF improvement vs non-improvement
Design
Retrospective cohort study
Authors
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LVEF improvement ≥10% post-CABG was associated with lower mortality; leaves open whether it should guide management or trial design in ischemic cardiomyopathy.
Cohort (n=362)
No
Does postoperative LVEF improvement predict better survival outcomes in patients with ischemic cardiomyopathy and preoperative LVEF < 50% undergoing CABG?
Hazard Ratio: 0.261 (95% CI 0.114–0.6)
Absolute Event Rate: 3.9% vs 13.5%
p-value: p=< 0.001
Early postoperative LVEF improvement (≥10%) at 6 months following CABG in patients with preoperative LV dysfunction is a strong predictor of long-term overall and event-free survival.
He et al. (2026) conducted a cohort in Ischemic cardiomyopathy with preoperative left ventricular dysfunction (n=362). Postoperative LVEF improvement (≥ 10% increase) vs. Postoperative LVEF non-improvement was evaluated on All-cause mortality (HR 0.261, 95% CI 0.114-0.600, p=< 0.001). Postoperative left ventricular ejection fraction improvement of ≥10% at 6 months after coronary artery bypass grafting significantly reduced the risk of all-cause mortality (HR 0.261) compared to non-improvement.
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