What does this research mean for the field?

The (pro)renin receptor gene polymorphism IVS5+169C>T is significantly associated with ambulatory blood pressure in Japanese men, indicating that (P)RR plays a role in human blood pressure regulation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

January 8, 2009American Journal of HypertensionOpen Access

Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study

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Why the study?

Are (pro)renin receptor gene polymorphisms associated with blood pressure in a Japanese population?

Population

1,112 Japanese subjects (357 men, 755 women) from the Ohasama cohort study

Comparison

RR gene polymorphisms vs Different genotypes/alleles of the same…

Design

Cohort

Authors

THTakuo HirosePreventive Cardiology MHMasahiro HashimotoJEOL (Japan)KTKazuhito TotsunePreventive Cardiology

Discussion

Member takes

Implication

Associated with higher ambulatory BP in Japanese men; hypothesis-generating for (pro)renin receptor variants, needs replication.

Structured PICO

Are (pro)renin receptor gene polymorphisms associated with blood pressure in a Japanese population?

Population

1,112 Japanese subjects (357 men, 755 women) from the Ohasama cohort study

Intervention

(P)RR gene polymorphisms (-782A>G, IVS5+169C>T, and +1513A>G)

Comparator

Different genotypes/alleles of the same polymorphisms (e.g., IVS5+169T allele carriers vs C allele carriers)

Outcome

Ambulatory blood pressure (24-h, daytime, and nighttime SBP and DBP) and casual blood pressuresurrogate

Cite This Study

Hirose et al. (2009) studied this question.

synapsesocial.com/papers/6a1ee3cf16625edd4004f9f2 https://doi.org/10.1038/ajh.2008.357

Topics

Hypertension management

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Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider