Key result
Off-pump coronary artery bypass grafting resulted in a similar mean ejection fraction at 6 months compared to on-pump grafting (36% vs 37%, P>0.05) in patients with poor left ventricular function.
Why the study?
More patients with severely impaired LV function are referred for CABG, but it is unclear whether the off-pump or on-pump technique is safer regarding cardiac function.
Does off-pump CABG improve cardiac function compared to on-pump CABG in patients with poor left ventricular function (EF 25-40%)?
Cohort (n=40)
Does off-pump CABG improve cardiac function compared to on-pump CABG in patients with poor left ventricular function (EF 25-40%)?
Absolute Event Rate: 36% vs 37%
p-value: p=>0.05
Both off-pump and on-pump CABG provide comparable and acceptable improvements in ejection fraction at 6 months for high-risk patients with poor left ventricular function.
Supports comparable EF recovery with off-pump CABG in poor LV function; hypothesis-generating and requires randomized confirmation.
Background: There is an increase in the number of patients with severely impaired left ventricle function who referred for CABG. Many studies showed that surgical intervention for those high-risk patients has high survival and wonderful outcome compared to medical treatment. Aim of work: This study aimed to evaluate our experience with coronary artery bypass surgery in patients with EF [ 25% up to 40%] either to perform surgery using off or on-pump technique and try to conclude which technique may be safer regarding cardiac function. Patients and Methods: This prospective observational patient cohort study from August 2017 to July 2019 enclosed forty consecutive patients divided into 2 teams every 20 patients either off or on pump technique according to surgeons' expertise. Pre-, intra- and post-operative data were collected for all patients. All survivors were subjected to a 6-months follow-up clinically and by Echocardiograghy assessment. Results: Improvement of ejection fraction [EF] was encountered in our study; the mean 6-months operative EF improved for each team by [36% versus 37%] for off-pump and on-pump interventions, respectively. There was no statistically important difference in the information collected for each technique [p-value>0.05] regarding most points of comparison. Conclusion: Results of CABG in high-risk patients were acceptable with on-pump and off-pump techniques with nearly comparable results in our study, at least in the early 6-months after intervention. Intra-aortic balloon usage is valuable when indicated.
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Asklany et al. (2020) conducted a cohort in Poor left ventricular function requiring CABG (n=40). Off-pump coronary artery bypass grafting vs. On-pump coronary artery bypass grafting was evaluated on Mean ejection fraction at 6 months (p=>0.05). Off-pump coronary artery bypass grafting resulted in a similar mean ejection fraction at 6 months compared to on-pump grafting (36% vs 37%, P>0.05) in patients with poor left ventricular function.
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