Key result
Off-pump coronary artery bypass surgery was associated with a significantly lower rate of total complications compared to conventional on-pump surgery, with no significant difference in mortality.
Why the study?
Does off-pump coronary artery bypass surgery reduce postoperative complications and hospital mortality compared to on-pump surgery in patients undergoing first-time CABG with severe left ventricular dysfunction?
Cohort (n=689)
Does off-pump coronary artery bypass surgery reduce postoperative complications and hospital mortality compared to on-pump surgery in patients undergoing first-time CABG with severe left ventricular dysfunction?
Off-pump CABG reduces postoperative complications compared to on-pump CABG in patients with severe left ventricular dysfunction, though it does not significantly impact hospital mortality.
Supports off-pump CABG to lower complications in severe LV dysfunction; hypothesis-generating, RCTs needed before practice change.
Our aim was to examine hospital outcomes of coronary artery bypass surgery in patients with and without left ventricular dysfunction, with regard to the surgical technique (off- or on-pump). Between March 2007 and March 2008, 689 consecutive patients underwent isolated first-time coronary artery bypass; 127 had ejection fractions < or = 30% (group 1) and 562 had ejection fractions >30% (group 2). Data of preoperative risk profiles and hospital outcomes were collected prospectively. Off-pump operations were performed in 49 (38.6%) patients in group 1 and 196 (34.9%) in group 2. The incidences of infectious, neurologic, and cardiac complications postoperatively were significantly higher in group 1. In multivariate analysis, preoperative ejection fraction < or = 30% was found to be an independent risk factor for postoperative complications and hospital mortality. The subgroup of patients undergoing off-pump surgery in both groups had a significantly lower rate of total complications than those undergoing conventional on-pump operations, but no significant difference in mortality was observed between those undergoing off-pump or conventional surgery in either group. Off-pump surgery helped to limit the increased morbidity rate after coronary bypass in patients with ventricular dysfunction.
No takes yet. Share an insight, caveat, or question.
Azarfarin et al. (2010) conducted a cohort in Coronary artery disease requiring bypass surgery (n=689). Off-pump coronary artery bypass surgery vs. Conventional on-pump coronary artery bypass surgery was evaluated on Postoperative complications and hospital mortality. Off-pump coronary artery bypass surgery was associated with a significantly lower rate of total complications compared to conventional on-pump surgery, with no significant difference in mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: