June 1, 1999British Journal of PharmacologyOpen Access

Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration

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Population

Rabbit aortic rings

Comparison

Nitric oxide donors (S-nitrosoglutathione [GSNO]… vs Basal conditions (no NO donor)

Design

Preclinical

Authors

CACharles Amirmansour PVPatrick VallanceThe University of Melbourne RBRichard BogleSt Helier Hospital

Discussion

Member takes

Implication

Does not support changing nitrate use; leaves open peroxynitrite contribution to human vascular effects.

Structured PICO

Population

Rabbit aortic rings

Intervention

Nitric oxide (NO) donors (S-nitrosoglutathione [GSNO] 1 x 10(-5)-3 x 10(-3) M or sodium nitroprusside [SNP] 1 x 10(-8)-1 x 10(-3) M)

Comparator

Basal conditions (no NO donor)

Outcome

Generation of superoxide (O2.-) and peroxynitrite (ONOO-) assessed by protein tyrosine nitrationsurrogate

Exogenous NO reacts with endogenous superoxide in blood vessels to form peroxynitrite, causing protein nitration, which suggests a potential mechanism for vascular damage during long-term nitrate therapy.

Cite This Study

Amirmansour et al. (1999) studied this question.

synapsesocial.com/papers/6a1eeb14d0800f8eb7c8dfb5 https://doi.org/10.1038/sj.bjp.0702590

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Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider