Population
In vitro and in vivo animal models including cardiac myocytes, endothelial cells, rat brain…
Design
Preclinical
Authors
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Nitrotyrosine should not yet inform clinical injury assessment; leaves open its value as a consistent biomarker in human NO-related disease.
While nitrotyrosine formation indicates increased NO generation in various pathological states, it is not a consistent marker for the severity of tissue injury.
Nakazawa et al. (2000) studied this question.
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