Why the study?
Does intradermal histamine or bradykinin increase NO concentration and dermal vascular perfusion in healthy human skin?
Does intradermal histamine or bradykinin increase NO concentration and dermal vascular perfusion in healthy human skin?
Endogenous NO increases during the inflammatory response to histamine in human skin, mediating increases in cGMP and microvascular perfusion.
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NO may mediate histamine-induced dermal perfusion in healthy skin; hypothesis-generating and leaves open relevance to inflammatory dermatoses.
Geraldine Clough (1999) studied this question.
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