Key result
The indirect flight muscles of Drosophila melanogaster offer a highly tractable in vivo model system to study developmental and adult myogenesis, as well as the mechanisms of human muscle diseases.
Why the study?
Myogenesis is a complex process, and indirect flight muscles in Drosophila melanogaster serve as a model for studying muscle development and disease.
Drosophila indirect flight muscles serve as a valuable in vivo model for understanding human muscle development, disease progression, and inter-organ communication.
Offers no immediate clinical implications for muscle disorders; leaves open expanded use of Drosophila models in myogenesis research.
Myogenesis is a complex multifactorial process leading to the formation of the adult muscle. An amalgamation of autonomous processes including myoblast fusion and myofibrillogenesis, as well as non-autonomous processes, such as innervations from neurons and precise connections with attachment sites, are responsible for successful development and function of muscles. In this review, we describe the development of the indirect flight muscles (IFMs) in Drosophila melanogaster, and highlight the use of the IFMs as a model for studying muscle development and disease, based on recent studies on the development and function of IFMs.
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Jawkar et al. (2020) conducted a review in Muscle development and disease. Drosophila melanogaster indirect flight muscles model was evaluated. The indirect flight muscles of Drosophila melanogaster offer a highly tractable in vivo model system to study developmental and adult myogenesis, as well as the mechanisms of human muscle diseases.
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