Key result
Alternative mRNAs for each of the four rat PMCA genes are expressed in a tissue-specific manner and encode enzyme variants with different combinations of calmodulin-binding domains and C termini.
Population
Rat plasma membrane Ca(2+)-ATPase (PMCA) mRNAs and corresponding genes
Design
Preclinical
Authors
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Tissue-specific PMCA variants in rats extend molecular characterization; leaves open cardiovascular functional roles in vivo.
The study demonstrates that alternative splicing of PMCA genes generates tissue-specific enzyme variants with distinct calmodulin-binding domains and C termini.
Keeton et al. (1993) studied this question. Alternative mRNAs for each of the four rat PMCA genes are expressed in a tissue-specific manner and encode enzyme variants with different combinations of calmodulin-binding domains and C termini.
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