September 14, 2004The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary BiologyOpen Access
Function follows form: Cardiac conduction system defects in Nkx2‐5 mutation
Population
Nkx2-5 knockout mouse models
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Advances Nkx2-5 conduction research in mice; hypothesis-generating without altering clinical practice.
Structured PICO
P
Population
Nkx2-5 knockout mouse models
I
Intervention
Nkx2-5 knockout/haploinsufficiency
O
Outcome
Cardiac conduction system development and electrophysiologic defects
Nkx2-5 mutations cause congenital heart block through developmental hypoplasia of the conduction system rather than direct alteration of electrophysiologic proteins.
Cite This Study
Jay et al. (2004) studied this question.