Key result
Atrial-restricted deletion of Nkx2-5 led to hyperplastic working myocytes and conduction system, demonstrating its suppressive role in cardiomyocyte proliferation via Notch signaling.
Population
Atrial-restricted Nkx2-5 deletion mutant models
Design
Preclinical
Authors
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Clarifies Nkx2-5's role in atrial proliferation without prior confounders; leaves open translation to human congenital defects.
Nkx2-5 suppresses the proliferation of atrial working and conduction myocardium in coordination with the Notch pathway.
Nakashima et al. (2014) studied Cardiomyocyte proliferation. Atrial-restricted deletion of Nkx2-5 was evaluated on Cardiomyocyte proliferation. Atrial-restricted deletion of Nkx2-5 led to hyperplastic working myocytes and conduction system, demonstrating its suppressive role in cardiomyocyte proliferation via Notch signaling.
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