Why the study?
Does pimobendan improve exercise capacity in patients with stable symptomatic heart failure?
Population
317 patients with stable symptomatic heart failure, objectively impaired exercise capacity, and an ejection…
Comparison
Pimobendan 2.5 mg and 5 mg daily added to… vs Placebo added to conventional treatment
Design
RCT, randomised, double blind
Follow-up
minimum 24 weeks
Authors
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Pimobendan may improve exercise tolerance in stable HF but trends toward higher mortality; challenges routine use and requires larger safety trials.
Does pimobendan improve exercise capacity in patients with stable symptomatic heart failure?
Pimobendan modestly improves exercise duration in heart failure patients but shows a concerning trend toward increased mortality.
Lubsen et al. (1996) studied this question.
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