Key result
Mediastinal radiation for Hodgkin's disease was associated with grade >1 aortic or mitral regurgitation in 24% of patients vs 0% of controls, with females at higher risk (OR 4.7).
Why the study?
Does mediastinal radiation for Hodgkin's disease increase the risk of late cardiac sequelae such as valve regurgitation in young adults?
Cohort (n=156)
Does mediastinal radiation for Hodgkin's disease increase the risk of late cardiac sequelae such as valve regurgitation in young adults?
Absolute Event Rate: 24% vs 0%
Mediastinal radiation for Hodgkin's disease is associated with a significantly increased risk of late left-sided valve regurgitation, particularly in females, warranting echocardiographic screening.
Authors
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May inform valvular surveillance in Hodgkin survivors; extends observational radiation toxicity data but leaves practice change open.
Lund et al. (1996) conducted a cohort in Hodgkin's disease (n=156). Mediastinal radiation vs. Healthy controls was evaluated on Grade > 1 aortic and/or mitral valvar regurgitation. Mediastinal radiation for Hodgkin's disease was associated with grade >1 aortic or mitral regurgitation in 24% of patients vs 0% of controls, with females at higher risk (OR 4.7).
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