December 1, 1990Journal of Biological ChemistryOpen Access

G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways.

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Population

Excised inside-out patches of apical membranes of A6 cells (renal epithelial cells)

Comparison

Pharmacological modulation using GTP gamma S… vs Untreated or pertussis toxin-treated patches

Design

Preclinical

Authors

HCHoracio F. CantielloNational University of Santiago del Estero CPC R PatenaudeHarvard University JCJuan CodinaElectrophysiology

Discussion

Member takes

Implication

Identifies a phospholipid pathway for Gi-ENaC activation in animals; leaves open its role in human sodium homeostasis.

Structured PICO

Population

Excised inside-out patches of apical membranes of A6 cells (renal epithelial cells)

Intervention

Pharmacological modulation using GTP gamma S, mepacrine, mellitin, arachidonic acid, nordihydroguaiaretic acid, leukotriene D4, and 5-hydroperoxyeicosatetraenoic acid

Comparator

Untreated or pertussis toxin-treated patches

Outcome

Na+ channel activity (percent open time and channel number)surrogate

Gi protein-mediated regulation of epithelial Na+ channels involves a phospholipid signal transduction pathway utilizing phospholipase and lipoxygenase.

Cite This Study

Cantiello et al. (1990) studied this question.

synapsesocial.com/papers/6a1efee6f3fddb4fc6b3074c https://doi.org/10.1016/s0021-9258(18)45786-9

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G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider