Key result
The alpha i-3 subunit, but not alpha i-2, stimulates Na+ channel activity and is part of the purified epithelial Na+ channel complex at the apical plasma membrane.
Population
Renal epithelial cell line A6
Design
Preclinical
Authors
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No immediate clinical implications from amphibian model; leaves open alpha i-3 targeting in mammalian sodium transport disorders.
The study demonstrates that the alpha i-3 subunit of the Gi-3 protein is an integral part of the epithelial Na+ channel complex and regulates its activity.
Ausiello et al. (1992) studied this question. alpha i-3 subunit vs. alpha i-2 subunit was evaluated on Na+ channel activity stimulation. The alpha i-3 subunit, but not alpha i-2, stimulates Na+ channel activity and is part of the purified epithelial Na+ channel complex at the apical plasma membrane.
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