Key result
Maceration of intracellular structures showed that the connective tissue skeleton contributes mainly to viscoelastic properties in initial deformations, while intracellular structures contribute under large deformations.
In papillary muscles, connective tissue dictates viscoelasticity at initial physiological deformations, while intracellular structures dominate at large deformations.
Suggests differential roles in animal cardiac viscoelasticity; leaves open validation in human myocardium before clinical relevance.
The biomechanical modeling of a papillary muscle preparation as an adequate object for studying the properties of the myocardial tissue under uniaxial stretching has been performed. The steady-state and relaxation tests of the papillary muscle of laboratory animals (rabbit and rat) have been conducted in normal conditions and after the maceration of intracellular structures with high ionic strength solution. It has been shown that the main contribution to the viscoelastic properties in the initial range of physiological deformations is made by the connective tissue skeleton, whereas under large physiological deformations, by intracellular structures.
No takes yet. Share an insight, caveat, or question.
Кобелев et al. (2011) studied this question. Maceration of intracellular structures with high ionic strength solution vs. Normal conditions was evaluated on Viscoelastic properties under uniaxial stretching. Maceration of intracellular structures showed that the connective tissue skeleton contributes mainly to viscoelastic properties in initial deformations, while intracellular structures contribute under large deformations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: