What question did this study set out to answer?

The aim is to understand the mechanisms behind changes in diastolic compliance in isolated mammalian cardiac muscle.

August 1, 1968Circulation ResearchOpen Access

Some Mechanical Properties of Isolated Mammalian Cardiac Muscle

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The aim is to understand the mechanisms behind changes in diastolic compliance in isolated mammalian cardiac muscle.
Isolated cardiac muscle preparations were analyzed at rest, during isometric and afterloaded contractions.
Experiments included programmed cyclic changes in length and paired stimulation with catecholamines and elevated extracellular calcium.
The influence of inotropic agents on the length-tension curve was primarily measured.
Experiments showed changes in compliance linked to the extensibility of the contractile element.
Stress-relaxation is governed by a viscous element in the cardiac muscle.
The rate and extent of relaxation during afterloaded contractions varied with the extent of shortening.

Structured PICO

Population

Isolated preparations of mammalian cardiac muscle

Intervention

Paired stimulation, catecholamines, and elevated extracellular calcium concentrations

Comparator

Rest and fixed initial length

Outcome

Changes in diastolic compliance and mechanical properties (length-tension curve, relaxation rate)surrogate

Basic science experiments on isolated mammalian cardiac muscle suggest that diastolic compliance changes are partly due to altered extensibility of the contractile element.

Discussion

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Implication

Extends basic mechanisms of diastolic compliance in isolated muscle; leaves open translation to intact hearts or clinical practice.

Cite This Study

Hoffman et al. (1968) studied this question.

synapsesocial.com/papers/6a23d9c32dc9ee5f679f03f5 https://doi.org/10.1161/01.res.23.2.291

View Full Paper

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Some Mechanical Properties of Isolated Mammalian Cardiac Muscle

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Some Mechanical Properties of Isolated Mammalian Cardiac Muscle

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider