November 1, 1977Circulation ResearchOpen Access

Altered performance of rat cardiac muscle follows changes in mechanical stress during relaxation.

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Population

Isolated rat trabecular muscle

Comparison

Loading which approximated that of the intact… vs Nonphysiological afterloaded isotonic contractions

Design

Preclinical

Authors

AWA. W. WiegnerUniversitätsklinik für Hals-, Nasen- und Ohrenheilkunde OBO. BingBoston University

Discussion

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Implication

Hypothesis-generating for load-dependent myocardial autoregulation; clinical relevance in humans remains untested.

Structured PICO

Population

Isolated rat trabecular muscle

Intervention

Loading which approximated that of the intact ventricle (lengthening at light loads)

Comparator

Nonphysiological afterloaded isotonic contractions (lengthening at the same load against which shortening had taken place)

Outcome

Mechanical performance (shortening and rate of shortening at constant load)surrogate

The study demonstrates an autoregulatory response of myocardium to mechanical stress during relaxation, where physiological loading conditions improve subsequent mechanical performance.

Cite This Study

Wiegner et al. (1977) studied this question.

synapsesocial.com/papers/6a911009504d7cdc493e8a04 https://doi.org/10.1161/01.res.41.5.691

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Altered performance of rat cardiac muscle follows changes in mechanical stress during relaxation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Altered performance of rat cardiac muscle follows changes in mechanical stress during relaxation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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