June 1, 1986AJP Heart and Circulatory Physiology

Relationship between inotropy and relaxation in rat myocardium

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Population

56 rat papillary muscles (early postpartum [1st day, 1st month] and adult)

Design

Preclinical

Authors

DCD. S. ChemlaUniversité Paris-Sud YLYves LecarpentierUniversité Claude Bernard Lyon 1 JMJackie L. MartinBarnes-Jewish Hospital

Discussion

Member takes

Implication

Rat data link inotropy to load-sensitive relaxation; extends mechanistic insights but leaves open human relevance.

Structured PICO

Population

56 rat papillary muscles (early postpartum [1st day, 1st month] and adult)

Intervention

Altering external calcium concentration ([Ca2+]0), stimulation frequency (F), and initial muscle length (L)

Outcome

Myocardial mechanics including load sensitivity of relaxation, peak shortening velocity, peak lengthening velocity, and contraction-relaxation coupling ratios (R1, R2)surrogate

In rat myocardium, modifying cardiac contractility through different mechanisms produces specific changes in contraction-relaxation coupling depending on the load.

Cite This Study

Chemla et al. (1986) studied this question.

synapsesocial.com/papers/6a779f60f6749a0058ec69aa https://doi.org/10.1152/ajpheart.1986.250.6.h1008

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Relationship between inotropy and relaxation in rat myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between inotropy and relaxation in rat myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider