Key result
A novel method using gas as a distending medium demonstrated that the Starling curve of isolated rabbit atria has a descending limb at high volumes, though requiring pressures that cause irreversible muscle changes.
Population
Isolated thin-walled cardiac chambers (rabbit atria)
Design
Preclinical
Authors
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Requires caution interpreting high-volume atrial function experimentally; extends gas-distension methods for isolated chamber studies.
A novel method using gas as a distending medium allows detailed study of myocardial contractility and pressure-volume relationships in isolated cardiac chambers.
John R. Blinks (1961) studied Isolated heart muscle contraction. Method using gas as distending medium and volume recorder was evaluated on Interrelations of temperature, interval between contractions, distending pressure, volume, amplitude of contraction, and pressure generated. A novel method using gas as a distending medium demonstrated that the Starling curve of isolated rabbit atria has a descending limb at high volumes, though requiring pressures that cause irreversible muscle changes.
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