Nature of PEVK-titin elasticity in skeletal muscle
Population
Rat psoas myofibrils
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Challenges pure entropic spring model for titin PEVK; leaves open enthalpic contributions to sarcomere mechanics in vivo.
Structured PICO
P
Population
Rat psoas myofibrils
I
Intervention
Mechanical stretch combined with immunofluorescence and immunoelectron microscopy using titin-specific antibodies
O
Outcome
Force-extension relation of the PEVK regionsurrogate
At physiological muscle lengths, the PEVK region of titin does not function as a pure entropic spring, but rather its elasticity has both entropic and enthalpic origins.
Cite This Study
Linke et al. (1998) studied this question.